Chicago: New Technologies Help Drugs Cross Blood-Brain Barrier
Designing compounds to fight neurodegenerative disease comes with the additional challenge of making sure they actually reach the brain...
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Designing compounds to fight neurodegenerative disease comes with the additional challenge of making sure they actually reach the brain...
Unfortunately, there is no quick test for predicting Alzheimer disease (AD)—at least not yet...
Ever since the ApoE4 allele was identified as a risk factor in late-onset Alzheimer's, researchers have speculated that ApoE interacts with β-amyloid. Several years ago, Kelly Bales and colleagues at Lilly Research Laboratories...
Two papers in today’s issue of Cell Stem Cell make one thing clear: the growth of new neurons relies on proper inhibitory GABA signaling...
The repertoire of the diminutive microRNA (miRNA) is growing by leaps and bounds...
Entire new classes of molecules don't come along every day, so it is worth noting that the classic triumvirate of RNA—mRNA, tRNA, rRNA—has just gotten a baby brother. Three independent research teams are reporting...
At this year’s annual meeting of the Society for Neuroscience, a grab bag of studies on the amyloid-β peptide highlighted some outstanding questions...
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) was originally conceived as an exploratory project to identify the best measures for tracking disease progression...
This report summarizes some of the genetic findings for late-onset Alzheimer's disease presented last November at the 33rd Annual Meeting of the Society for Neuroscience in New Orleans...
In today's Journal of Cell Biology, researchers of the University of Maryland Biotechnology Institute (UMBI) report that a molecule called ubiquilin regulates levels of presenilins, and is "highly expressed" in human neurons...
Recently, the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, hosted reporters for a day of talks on...
Douglas Kerr and colleagues at Johns Hopkins (Abstract 209.13) reported success in using neural stem cells to restore function in an animal model of spinal motor atrophy (SMA). In SMA, the ventral horn motor neurons...
From today's Science: Researchers have built a microarray designed to study the interactions of thousands of proteins simultaneously, helping to uncover their function...
This story is a continuation of the St. Moritz series started on Monday, 24 May 2004...
Japanese scientists have now incorporated an unusual variant of amyloid precursor protein (APP) into a new mouse model...