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The AMPA Receptor Steps out of the Shadows

Researchers studying the molecular basis of long-term potentiation (LTP) have typically focused on the role of NMDA glutamate receptor, but two papers published in the June 11 issue of Science elucidate the role of the other glutamate receptor, the AMPA receptor...

Biochemical Mechanisms of Long-Term Memory

Evidence from several sources suggests that the dorsal hippocampus is critical for the formation and storage of spatial information. In the long term, such information is believed to be transferred to the neocortex for storage...

Of Presenilins and Armadillos

The armadillo gene—so named because its mutated form in fruit flies produces a phenotype with short spiky hairs, reminiscent of those on the armadillo—codes for a protein that is a homologue of the human β-catenin...

Watching Enzymes at Work

Three-dimensional images of enzymes at work in cells? This is the promise of a new advance in microscopy called fluorescence lifetime imaging microscopy (FLIM)...

More Details to the β-catenin Picture

β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin...

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