There’s a GSAP for That: Novel APP Partner a New Therapeutic Target?
A paper reports the discovery of a γ-secretase activating protein (GSAP) that acts specifically to promote the binding of γ-secretase to APP, but not to Notch...
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A paper reports the discovery of a γ-secretase activating protein (GSAP) that acts specifically to promote the binding of γ-secretase to APP, but not to Notch...
Researchers report that covalently constraining Aβ monomers into a specific β-hairpin structure accelerates formation of toxic oligomers...
The neurotransmitter norepinephrine seems to help resident phagocytes clear the Aβ peptides that accumulate in the brains of Alzheimer disease patients...
Non-pharmacologic approaches, such as one reported in this week’s JAMA, may yet offer the best hope for finding peace amid mental decline...
To release neurotransmitters, nerve terminals must repeatedly break down and rebuild specialized protein complexes, and the fidelity of this process may rely on α-synuclein...
Researchers have mediated a merger of sorts between two distinct neurodegenerative conditions—ALS and (SCA)—and the proteins that cause them...
Having diabetes seems to drive up risk for dementia, including Alzheimer disease, but the jury has been out as to how this occurs...
The majority of patients with Parkinson disease eventually develop dementia, but what pathology underlies this decline?...
The misfolded enzyme that causes some kinds of amyotrophic lateral sclerosis poisons motor neurons by plugging up pores in their mitochondria...
Several studies have shown that Alzheimer’s patients appear to be less susceptible to cancer, but the mechanism behind this association remains mysterious...
Getting hit in the head might not just ring your bell—in rare cases, it may predispose athletes in contact sports to motor neuron disease...
Surprisingly little is known about how AD affects the electrical activity of the hippocampus...
Mounting evidence suggests that immune system molecules can wear different hats in the central nervous system...
There is a new ingredient in the complex mix that yields masses of malformed proteins...
Inhibition of the β-secretase enzyme has long been seen as one of the most promising therapeutic options for Alzheimer disease...
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