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Finally, a Mitochondrial Mutant

A feat that has eluded researchers for some time—the creation of an animal model of human mitochondrial DNA (mtDNA) diseases—has finally been accomplished. Japanese researchers report that they have created mutant mice with a large-scale mtDNA deletion...

Another Role for the Prion: Evolutionary Key?

The prion protein, so interesting to researchers of neurodegenerative disease for its novel capacity to cause disease through a change of conformation—and to transmit disease to other cells and organisms through its altered conformation—may have...

News Commentary on Nicastrin

Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2...

Going Beyond the DNA

High-throughput screening for proteins is now possible, according to report in this month's Nature Biotechnology. Researchers in England have designed an array, similar to DNA microarrays, that can screen for more than 18,000 proteins at once...

ApoE(ε)4 Brains Have to Work Harder

The ε4 variant of the apolipoprotein-E (ApoE) gene has been shown to confer increased risk for Alzheimer's disease. Gary Small, Susan Bookheimer, and colleagues report that carriers of the ε4 allele need to exert their brains more...

NFTs in Mice

Mice carrying the P301 mutation in tau, which causes human frontotemporal dementia, develop neurofibrillary pathology with features mimicking those of human tauopathies...

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