Improved magnetic resonance imaging methods confirm damage in a subclass of motor neurons in ALS.
In a reverse twist on the spread of pathology in Alzheimer’s, axonal proteins translated in the presence of Aβ migrate back to cell bodies, where they promote cell death.
Aβ in mitochondria slows the maturation of proteins that enter the organelle from cytosol, according to a new study. The finding could help explain the wide range of mitochondrial deficits seen in Alzheimer’s disease.
Restraining the activity of a calcium-activated phosphatase may take the edge off a-synuclein toxicity.
According to new research, as both mice and humans grow older, immune signals change at the interface between blood and cerebrospinal fluid.
Perfectly healthy mitochondria can sicken neurons simply by being in the wrong place.