Researchers have modeled a motor neuron in silico to show how energy shortage could lead to its degeneration in amyotrophic lateral sclerosis.
An active immunotherapy is coming to the fore as researchers continue to try novel therapies.
Repeat peptides made by the mutant C9ORF72 gene in ALS and FTD enter the nucleolus and obstruct RNA biogenesis.
Signals emanating from the prefrontal cortex play a role in forming memories in the hippocampus, a study reports. The finding could have implications for Alzheimer’s.
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Lifestyle changes to evade dementia, such as healthy eating and exercise, made a strong showing at the Alzheimer’s Association International Conference in Copenhagen, Denmark.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
In mouse models, Aβ aggregates injected into the belly invade the brain, as do prion seeds.
New data strengthens the evidence that dementia risk is dropping in developed countries, possibly due to better education and heart health.
Researchers will have full access to a gargantuan genetic meta-analysis on the newly revamped PDGene database.
A global effort to combat dementia has been conducting a yearlong series of events. Alzforum spoke with Dennis Gillings, who chairs the new World Dementia Council.
A mouse study testing the combined effects of a BACE inhibitor and plaque-clearing antibody builds new support for a combination strategy aimed at reducing Aβ buildup in people.
Could tweaking methodologies improve amyloid diagnosis and tracking?
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
Mutated huntingtin may stow away in synaptic vesicles to sneak from one neuron to another.