Alpha-secretase does not necessarily pick up the slack when β-secretase cleavage of amyloid precursor protein wanes, a study in primates finds. It suggests APP can be processed in other ways.
Belying some earlier reports, a new study finds that grafted dopamine cells continue to innervate neural networks years after transplantation.
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
Patient-derived macrophages are the latest model of Gaucher’s disease, a lysosomal storage disorder. The cells may help researchers better understand disease phenotypes and test candidate therapies.
Does amyotrophic lateral sclerosis start at the interface between mitochondria and the endoplasmic reticulum?
While scientists remain on the fence over whether computer games benefit cognition, some are finding new uses for gaming data in clinical trial research.
Brain-training websites tout their games’ potential to boost cognition, but strong evidence and firm backing by the scientific community have yet to surface.
In mouse models, the Alzheimer’s risk gene TREM2 affects microglial behavior but does not lead to more amyloid deposition.
While mice sleep, neurons sprout synapses to solidify fresh skills, according to a new study. The brain also keeps amyloid-β levels low while we snooze.
Supplements of resveratrol, a compound found in red grapes and wine, improved memory, metabolism, and brain connectivity in a group of overweight older adults.
Researchers link frontotemporal dementia pathology to DNA damage.
AFFiRiS AG claims that a placebo formulation, not their active Aβ vaccine, slowed the progression of Alzheimer's disease in a Phase 2 study.
The ADCS–PACC, a new cognitive composite test to be used in the A4 prevention trial, detects subtle deficits in older adults with brain amyloid.
Big-data project takes on Alzheimer's with a biomarker computational challenge.