Brain Connectivity Reveals Preclinical Alzheimer’s Disease
Brain connections weaken years before cognition in sporadic and familial Alzheimer’s.
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Brain connections weaken years before cognition in sporadic and familial Alzheimer’s.
Is transfer of tau from one neuron to the next a normal activity, hijacked by pathogenic protein in the case of tauopathies?
Expansions in ataxin-2 can lead to either ALS or spinocerebellar ataxia—even in the same family, according to a new pedigree from New York.
Two studies examine factors that heighten the risk for dementia in type 2 diabetes patients. Both highlight depression as a dangerous comorbidity.
Studies support the idea that mitochondrial changes drive aging and AD pathogenesis.
A parkinsonism-associated ubiquitin ligase interacts with parkin to promote mitophagy.
Researchers identified a genetic variant in the microglial gene CD33 that protects against Alzheimer’s.
Alzheimer’s and prion disease may be linked through an α-secretase.
The route to early dementia starts in adolescence, with low cognitive function and alcohol intoxication as major predictors.