Notch Your Average Joe—Grounds for PS1 Neurogenesis Inhibition?
Notch, that pesky “other” γ-secretase substrate, mediates adult neurogenesis defects attributed to presenilin-1 (PS1) mutations...
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Notch, that pesky “other” γ-secretase substrate, mediates adult neurogenesis defects attributed to presenilin-1 (PS1) mutations...
Scientists propose that Auguste Deter, the first identified Alzheimer disease patient, carried the N141I presenilin-2 mutation...
Rebounds leave basketball fans on the edge of their seats. They can also leave drug developers with bated breath—rebounds of the Aβ kind, that is...
By some measures, ApoE found its first companions in 2009 when scientists reported three additional genes robustly linked to late-onset Alzheimer disease...
There may be a new glimmer of hope for patients with Huntington disease (HD)...
Somewhere on the short arm of the ninth chromosome, there lies a locus, or loci, that can cause amyotrophic lateral sclerosis (ALS) or frontotemporal lobar dementia (FTLD)...
Here we list the 39 abstracts presented at the Human Amyloid Imaging Conference held 9 April 2010 in Toronto, Canada...
Geneva: At Springfield Meeting, Soul-Searching About Dearth of Drugs Geneva: Biomarker News Morsels Amid Immunotherapy Review Geneva: The AstraZeneca Ligand—The Fairest of Them All? International Geneva/Springfield Symposium on Advances in Alzheimer Thera
This story ends with a glimpse of the newest kid on the block—18F AZD4694...
At the 4th Human Amyloid Imaging Conference, one 18F amyloid ligand strutted its Phase 3 stuff, while two others flaunted Phase 2 results...
A much greater investment in AD research will be needed before scientists can draw reliable conclusions about what factors increase or decrease risk of developing AD...
The finger pointing in the molecular culprit behind AD has shifted in recent years from amyloid plaques to its building blocks—free-floating Aβ peptides...
Several recent studies have shown that memory formation, learning, and age-associated cognitive decline are linked to remodeling of chromatin proteins...
At present, at least four companies are developing amyloid imaging agents coupled to the radiotracer 18F rather than 11C...
At the 4th Human Amyloid Imaging Conference, the question kept cropping up of what is the right reference region to use in amyloid imaging...