Kiss of Life: Stem Cells Use Gap Junctions to Revive Neurons
Neuronal stem cells are proving to function like capable paramedics, coming to the rescue of degenerating neurons in multiple animal models of disease...
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Neuronal stem cells are proving to function like capable paramedics, coming to the rescue of degenerating neurons in multiple animal models of disease...
Mitochondria take the stage in three recent papers...
There are times in the course of scientific enterprise when researchers must re-evaluate their hypotheses in the face of new, unexpected data...
The new animal models for TDP-43 proteinopathies, a series of related neurodegenerative diseases, are coming out at a fast and furious rate...
The cellular prion protein has received a lot of attention recently for its potential role in amyloid-β (Aβ) toxicity...
Death and taxes are reputedly inevitable, though death and receptors may be more interesting to Alzforum readers...
Bigger, smarter, and more amenable than mice to the imaging techniques that are rapidly becoming indispensable in AD research, rats could be a valuable model for studying AD...
Gizem Donmez reported that SIRT1 might protect against AD by boosting ADAM10 (aka α-secretase) and promoting non-amyloidogenic processing of Aβ APP...
While too little calcium can trigger bone problems, insufficient magnesium may spell trouble for your brain...
A fruit fly is joining the menagerie of TDP-43 animal models, bringing the power of <em>Drosophila</em> genetics to the lab bench...
NMDA receptors populate the synapse, where they participate in nerve signaling and promote cell survival pathways; but those same receptors can activate apoptosis...
It’s time to cut out the middleman—why go from fibroblasts, to induced pluripotent stem cells, to neurons, if one can skip straight to the payload?...
Though ApoE4 genotype has for years topped the list of genetic risk factors for AD, scientists grapple with how this allele makes people more prone to AD...
In an organ as highly vascular as the brain, optimal performance depends on keeping the plumbing shipshape...
When it comes to the synaptic toxicity and cognitive dysfunction in AD, a preponderance of evidence points to soluble oligomers of Aβ peptides as the main villains...