Sorrento: Sorting Out Shedding of Ectodomains
Not only the sweet scent from the ubiquitous citrus trees aroused the senses at the 7th international AD/PD meeting in Sorrento, but the unlikely theme of...
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Not only the sweet scent from the ubiquitous citrus trees aroused the senses at the 7th international AD/PD meeting in Sorrento, but the unlikely theme of...
Four new mouse studies sketch how molecular alterations involving neuregulin-1 (Nrg1) might lead to neurological and behavioral deficits in schizophrenia...
What makes amyloid-β (Aβ) polymerize?...
Much more than palm leaves swaying in the breeze along a sandy beach distinguished the 5th Human Amyloid Imaging (HAI) conference...
When amyloid-β (Aβ) peptides get together, the trouble starts. A conformational change in Aβ, followed by...
Two current reviews lay out the current understanding of the role of protein-folding assistants and protein grinders in neurodegenerative diseases.
A γ-secretase inhibitor that doesn’t block γ-secretase may seem like a bit of an oxymoron, but there are some compounds that appear to do just that...
Rebounds leave basketball fans on the edge of their seats. They can also leave drug developers with bated breath—rebounds of the Aβ kind, that is...
A compound that blocks both β- and γ-secretase might tone down production of amyloid-β (Aβ) and perhaps slow or prevent Alzheimer disease...
Years of research have fingered presenilin as the γ-secretase component that slices amyloid precursor protein (APP) to release amyloid-β...
Everyone with even a passing interest in Alzheimer disease has seen a sepia-toned photograph of its namesake like the one...
The prion protein, so interesting to researchers of neurodegenerative disease for its novel capacity to cause disease through a change of conformation—and to transmit disease to other cells and organisms through its altered conformation—may have...
The dominant theory of Alzheimer's disease is that insoluble aggregates of amyloid-β (Aβ) are the neurotoxic entity that causes neuronal dysfunction and cell death...
In the current issue of Science, researchers report that CREST—a protein that interacts with CREB (cAMP response element-binding protein) binding protein, or CBP—is required for proper dendritic growth in neurons...
How to protect the proteins in the cell that protect other proteins—the chaperones...