Going Nuclear: First Function for FUS Mutants
Large proteins need a key—in the form of a nuclear localization sequence—to unlock the transporters that let them into the cell’s inner sanctum...
6381 RESULTS
Sort By:
Large proteins need a key—in the form of a nuclear localization sequence—to unlock the transporters that let them into the cell’s inner sanctum...
Consciousness is like beauty: We all know subjectively what it is, but it is very hard to define concisely...
A compound that blocks both β- and γ-secretase might tone down production of amyloid-β (Aβ) and perhaps slow or prevent Alzheimer disease...
As denim trumps other fabrics in durability and longevity, genes may beat the pants out of diet and lifestyle in determining whether you’ll live to 100...
St. Louis: ApoE Receptors—Hold Sway Over Synaptic Function St. Louis: ApoE—Receptors, Theories and Therapies St. Louis: ApoE—A Clearer View of its Role In AD? The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease.
ApoE receptors enable a flurry of activity, much of it totally independent of amyloid-β pathology...
It failed in the large Ginkgo of Memory (GEM) prevention trial, but companies are still betting ginkgo biloba extract is a valuable anti-dementia agent...
A potential therapeutic strategy for Alzheimer disease (AD) is to inhibit the BACE enzymes that kickstart processing of amyloid precursor protein (APP) to form Aβ...
Microarrays tantalize investigators with the promise of a new smorgasbord of genes to explore and proteins to target with therapeutics...
During the late 1980s and the 1990s, tissue grafts, chosen to replace lost dopaminergic neurons, seemed to show great promise for the treatment of Parkinson disease...
Misfolded proteins can gum up the cell’s works by glomming together and boosting inflammation...
ApoE stands out for a frustrating mark of distinction...
The apolipoprotein E gene is the strongest genetic risk factor for late-onset Alzheimer disease...
Sifting through the genome has netted several mutations responsible for motor neuron diseases, but scientists still cannot explain the cause for most incidences...
Bethesda: Dawn of the Epigenetics Era Bethesda: The Methylated Brain Bethesda: "Ome" Sweet "Ome"—Epigenome Joins Genome, Proteome Epigenetics, the "software" that interprets information stored in the DNA "hardware,"