Metabolomics: Seeking Biomarkers for ALS, Parkinson’s, Huntington’s
Metabolomics has given researchers studying Alzheimer’s disease plenty to think about...
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Metabolomics has given researchers studying Alzheimer’s disease plenty to think about...
Readers could be forgiven for doing a double-take at the title of a recent paper linking APP—best known for its role in Alzheimer’s disease—to ALS...
In this month's Journal of Medical Genetics, a group of Italian researchers propose that there is a link between longevity and a single nucleotide polymorphism (SNP) in the promoter for the antiinflammatory cytokine interleukin-10 (IL-10)...
In the July 8 issue of Current Biology, researchers at the University of California, Los Angeles, and Kyoto University, Japan, reveal that mice carrying a mutated version of the Notch gene suffer from spatial learning and memory defects...
Our understanding of amyloid precursor protein’s (APP’s) effects on the cell gained new insight this week...
Mutations in the gene encoding LRRK2 (aka tyrosine kinase leucine-rich repeat kinase 2) are the most common cause of hereditary Parkinson disease...
In neurons, not all introns are left on the nuclear cutting-room floor...
Several studies have shown that Alzheimer’s patients appear to be less susceptible to cancer, but the mechanism behind this association remains mysterious...
Researchers report that immediate versus gradual application of brain-derived neurotrophic factor (BDNF) has “dramatically” different results for cultured neurons...
Researchers report that PS1 modulates homeostatic synaptic scaling, a type of synaptic plasticity that functions at the level of neuronal networks...
Researchers led by Dennis Selkoe offer what he considers the “cleanest, best-controlled evidence to date” for the toxicity of small amyloid-β oligomers...
Researchers report that the let-7 family of miRNAs seeks out Toll-like receptor 7, quickly obliterating neurons...
It appears that some tauopathies require the presence of neurofilaments for neurodegeneration to occur. In the 15 August Journal of Neuroscience, Virginia Lee, Takeshi Ishihara, and colleagues at the University of Pennsylvania describe...
Even though ApoE stands head and shoulders above other genetic risk factors for late-onset AD, few therapeutic strategies aimed at ApoE have made it to clinical trials...
An active vaccine against a small piece of the Aβ42 protein is both safe and tolerable in patients with mild to moderate Alzheimer's disease...