One Small Molecule Detoxifies Different Forms of Aβ
In recent years, mounting evidence has pointed to soluble oligomers of Aβ, rather than amyloid fibrils, as the most toxic species in AD...
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In recent years, mounting evidence has pointed to soluble oligomers of Aβ, rather than amyloid fibrils, as the most toxic species in AD...
How does a nice (that is, soluble and relatively unstructured) protein like tau end up rigidly locked into paired helical filaments and neurofibrillary tangles?...
In response to rising calls for action, last year, the Alzheimer’s Study Group (ASG) was formed...
Comparing neuropsychological test results against age-adjusted norms is one way of determining whether an individual might be facing impending dementia...
At the International Conference for Alzheimer’s Disease, several investigators presented data on compounds in Phase 2...
Fundamental knowledge gaps in Alzheimer disease research include a clear grasp of the normal role of the amyloid precursor protein (APP), and the molecular basis for the increased risk for AD as people age...
In Greek mythology, Klotho is a goddess of fate. She spins the thread of life...
Two recent papers show how peripheral inflammation can intensify central nervous system (CNS) damage...
Researchers report that they have developed a small molecule that acts specifically on the M4-type muscarinic acetylcholine receptors (mAChRs)...
Much of the data generated from drug trials on human volunteers stays hidden from view, sometimes to the detriment of patients...
The results of ADNI are arriving at two different levels...
Typically, a large investment in big science attracts ideas on how to get more bang for the buck once the original study is on its way...
The apolipoprotein E4 allele (ApoE4) is the most prominent genetic risk factor for late-onset Alzheimer disease (LOAD), but it is not the whole story...
It appears that Dublin-based Elan's small molecule drug candidate ELND005 has run into some trouble...
The table of evidence regarding inflammatory and even autoimmune processes in Alzheimer's continues to accumulate in a piecemeal fashion, awaiting experimental breakthroughs to give it direction and a greater following. But accumulate it does, and in this article we summarize some of the recent appetizers...