ALS—A Polyglutamine Disease? Mid-length Repeats Boost Risk
Researchers have mediated a merger of sorts between two distinct neurodegenerative conditions—ALS and (SCA)—and the proteins that cause them...
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Researchers have mediated a merger of sorts between two distinct neurodegenerative conditions—ALS and (SCA)—and the proteins that cause them...
Having diabetes seems to drive up risk for dementia, including Alzheimer disease, but the jury has been out as to how this occurs...
The majority of patients with Parkinson disease eventually develop dementia, but what pathology underlies this decline?...
The misfolded enzyme that causes some kinds of amyotrophic lateral sclerosis poisons motor neurons by plugging up pores in their mitochondria...
Several studies have shown that Alzheimer’s patients appear to be less susceptible to cancer, but the mechanism behind this association remains mysterious...
Getting hit in the head might not just ring your bell—in rare cases, it may predispose athletes in contact sports to motor neuron disease...
Surprisingly little is known about how AD affects the electrical activity of the hippocampus...
Mounting evidence suggests that immune system molecules can wear different hats in the central nervous system...
There is a new ingredient in the complex mix that yields masses of malformed proteins...
Inhibition of the β-secretase enzyme has long been seen as one of the most promising therapeutic options for Alzheimer disease...
Eli Lilly and Company announced yesterday that it has halted its Semagacestat γ-secretase inhibitor program...
There is a new TDP-43 mouse in town...
A γ-secretase inhibitor that doesn’t block γ-secretase may seem like a bit of an oxymoron, but there are some compounds that appear to do just that...
A new study suggests that age-related protein aggregation might be widespread even in healthy organisms...
In clinical research, a first-time finding may rouse intrigue, but it’s generally independent confirmations of the data that give them potential to leave an indelible mark...
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