All Comments by Takaomi Saido

  1. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial.
  2. A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.
  3. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
  4. Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins.
  5. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.
  6. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome.
  7. APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42.
  8. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.
  9. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
  10. Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.
  11. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.
  12. Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation.
  13. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry.
  14. The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation.
  15. Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation.