All Comments by Takaomi Saido

  1. Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia.
  2. Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis.
  3. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
  4. Polymorphism in the BACE gene influences the risk for Alzheimer's disease.
  5. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
  6. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.
  7. Mutations in dynein link motor neuron degeneration to defects in retrograde transport.
  8. Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide.
  9. Generation of functional inhibitory neurons in the adult rat hippocampus.
  10. Discovery of compounds that will prevent tau pathology.
  11. Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus.
  12. β Amyloid Degradation: The Forgotten Half of Alzheimer's Disease
  13. β Amyloid Degradation: The Forgotten Half of Alzheimer's Disease