All Comments by John Hardy

  1. Alzheimer’s Vaccine: In Some Patients, at Least, It Might Just Work
  2. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.
  3. A patient with dementia with Lewy bodies and codon 232 mutation of PRNP.
  4. BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein.
  5. D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype.
  6. The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
  7. Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.
  8. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.
  9. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning.
  10. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
  11. Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10cM resolution.
  12. Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
  13. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
  14. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
  15. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.