All Comments by Edward Koo

  1. Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.
  2. Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain.
  3. Alpha-synuclein-immunoreactive deposits in human and animal prion diseases.
  4. Peeling plaque. Researchers remain optimistic about a vaccine against Alzheimer's.
  5. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
  6. Imaging hippocampal function across the human life span: is memory decline normal or not?
  7. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  8. The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.
  9. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
  10. Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
  11. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
  12. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
  13. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
  14. Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
  15. Copernicus revisited: amyloid beta in Alzheimer's disease.