All Comments by Edward Koo
- Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.
- Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain.
- Alpha-synuclein-immunoreactive deposits in human and animal prion diseases.
- Peeling plaque. Researchers remain optimistic about a vaccine against Alzheimer's.
- FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
- Imaging hippocampal function across the human life span: is memory decline normal or not?
- Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
- The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.
- APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
- Endoplasmic reticulum stress-induced cysteine protease activation in cortical neurons: effect of an Alzheimer's disease-linked presenilin-1 knock-in mutation.
- FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
- Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
- A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
- Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
- Copernicus revisited: amyloid beta in Alzheimer's disease.