All Comments by Nikolaos K. Robakis

  1. Genetic association between alpha-2 macroglobulin and Japanese sporadic Alzheimer's disease.
  2. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.
  3. Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.
  4. The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.
  5. Wide range of disease onset in a family with Alzheimer disease and a His163Tyr mutation in the presenilin-1 gene.
  6. Striation is the characteristic neuritic abnormality in Alzheimer disease.
  7. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
  8. Genetic studies on chromosome 12 in late-onset Alzheimer disease.
  9. Laminin inhibits Abeta42 fibril formation in vitro.
  10. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.
  11. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
  12. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.
  13. Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype.
  14. Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest.
  15. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease.