All Comments by Nikolaos K. Robakis

  1. Evidence that intramolecular associations between presenilin domains are obligatory for endoproteolytic processing.
  2. Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele.
  3. Apolipoprotein E isoform-specific reduction of extracellular amyloid in neuronal cultures.
  4. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease.
  5. Melatonin protects hippocampal neurons in vivo against kainic acid-induced damage in mice.
  6. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.
  7. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
  8. Carnosine, a protective, anti-ageing peptide?
  9. Rapid tau protein dephosphorylation and differential rephosphorylation during cardiac arrest-induced cerebral ischemia and reperfusion.
  10. Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients.
  11. Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest.
  12. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
  13. Somatic mutation analysis of the APP and Presenilin 1 and 2 genes in Alzheimer's disease brains.
  14. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.
  15. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.