All Comments by Jürgen Götz

  1. Extracting β-amyloid from Alzheimer's disease.
  2. Atomic identification of fluorescent Q-dots on tau-positive fibrils in 3D-reconstructed pick bodies.
  3. Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations.
  4. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.
  5. Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.
  6. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial.
  7. Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
  8. The Plot Thickens: The Complicated Relationship of Tau and Aβ
  9. The Alzheimer's disease mitochondrial cascade hypothesis.
  10. Caspase activation precedes and leads to tangles.
  11. Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein.
  12. Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology.
  13. Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila.
  14. Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?
  15. New Retro: Mouse Gene Tweaks Both Aβ, Tau Pathology via GSK3