All Comments by Hiroshi Mori

  1. Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.
  2. Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement.
  3. Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.
  4. Melatonin prevents beta-amyloid-induced lipid peroxidation.
  5. Interaction of apolipoprotein E epsilon 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator.
  6. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
  7. Multiple pathways of apoptosis in PC12 cells. CrmA inhibits apoptosis induced by beta-amyloid.
  8. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
  9. Assembled tau filaments differ from native paired helical filaments as determined by scanning transmission electron microscopy (STEM).
  10. Complete genomic screen in late-onset familial Alzheimer's disease.
  11. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
  12. Apolipoprotein E phenotype is not related to late-life depression in a population-based sample.
  13. Effects of specific protease inhibitors on amyloid beta-protein 42 secretion.
  14. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.
  15. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.