All Comments by Hiroshi Mori

  1. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
  2. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
  3. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.
  4. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.
  5. alpha-Synuclein membrane interactions and lipid specificity.
  6. Glucocorticoids in Alzheimer's disease. The story so far.
  7. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt.
  8. Regionally specific neuronal expression of human APOE gene in transgenic mice.
  9. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
  10. Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.
  11. Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia.
  12. Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE.
  13. Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells.
  14. Discontinuous distribution of senile plaques within striate cortex hypercolumns in Alzheimer's disease.
  15. Alpha-secretase-derived product of beta-amyloid precursor protein is decreased by presenilin 1 mutations linked to familial Alzheimer's disease.