All Comments by Edward Koo

  1. Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.
  2. Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain.
  3. Alpha-synuclein-immunoreactive deposits in human and animal prion diseases.
  4. Peeling plaque. Researchers remain optimistic about a vaccine against Alzheimer's.
  5. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
  6. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain.
  7. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis.
  8. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
  9. Copernicus revisited: amyloid beta in Alzheimer's disease.
  10. A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis.
  11. Gamma-secretase-like cleavages of Notch and beta APP are mutually exclusive in human cells.
  12. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.
  13. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease.
  14. Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide.
  15. APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.