All Comments by Edward Koo
- Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
- Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.
- The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
- Trials and Tribulations: Does ADAPT Have to Adapt?
- Caspase inhibition protects nerve terminals from in vitro degradation.
- PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
- Abnormal cerebellar signaling induces dystonia in mice.
- Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide.
- The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration.
- An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
- Analysis of tau haplotypes in Pick's disease.
- Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.
- In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease.
- Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).
- Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.