All Comments by Edward Koo
- Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.
- Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease.
- Caspase-cleaved amyloid precursor protein in Alzheimer's disease.
- NACP/alpha-synuclein, NAC, and beta-amyloid pathology of familial Alzheimer's disease with the E184D presenilin-1 mutation: a clinicopathological study of two autopsy cases.
- Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
- Serum insulin-like growth factor I regulates brain amyloid-beta levels.
- Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide.
- Assessment of low-flow CSF drainage as a treatment for AD: results of a randomized pilot study.
- Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.
- Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
- Alzheimer's disease can be accurately diagnosed in very mildly impaired individuals.
- Rates of progression in mild cognitive impairment and early Alzheimer's disease.
- Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
- Alzheimer's second patient: Johann F. and his family.
- Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.