All Comments by Sam Gandy

  1. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.
  2. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
  3. β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.
  4. Testing the right target and right drug at the right stage.
  5. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.
  6. Neuronal activity regulates the regional vulnerability to amyloid-β deposition.
  7. Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
  8. Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.
  9. Vienna: New Genes, Anyone? ICAD Saves Best for Last
  10. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.
  11. Philadelphia: European Trial of Alzhemed Ends, Marketing Morphs to Supplement
  12. Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex.
  13. What Role Brain Statins—Sparing Isoprenoids from the Rac?
  14. Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death.
  15. Chronic traumatic encephalopathy in a national football league player: part II.