All Comments by Sam Gandy
- Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.
- Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
- β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.
- Testing the right target and right drug at the right stage.
- LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.
- Neuronal activity regulates the regional vulnerability to amyloid-β deposition.
- Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.
- Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.
- Vienna: New Genes, Anyone? ICAD Saves Best for Last
- Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.
- Philadelphia: European Trial of Alzhemed Ends, Marketing Morphs to Supplement
- Interactive effects of age and estrogen on cognition and pyramidal neurons in monkey prefrontal cortex.
- What Role Brain Statins—Sparing Isoprenoids from the Rac?
- Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death.
- Chronic traumatic encephalopathy in a national football league player: part II.