All Comments by Benjamin Wolozin

  1. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau.
  2. Function of beta-amyloid in cholesterol transport: a lead to neurotoxicity.
  3. Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease.
  4. Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.
  5. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
  6. Proteasome inhibition causes nigral degeneration with inclusion bodies in rats.
  7. Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.
  8. Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice.
  9. Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.
  10. Presenilins are not required for A beta 42 production in the early secretory pathway.
  11. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.
  12. Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy.
  13. Presenilin-2 (PS2) expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis.
  14. Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.
  15. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.