All Comments by Benjamin Wolozin

  1. Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
  2. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
  3. Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain.
  4. Anti-amyloidogenic activity of tetracyclines: studies in vitro.
  5. Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response.
  6. Identification of estrogen target genes in human neural cells.
  7. MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males.
  8. Presenilin-1 mutations in Alzheimer's disease.
  9. Essential role for cholesterol in synaptic plasticity and neuronal degeneration.
  10. Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
  11. Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.
  12. Susceptibility locus for Alzheimer's disease on chromosome 10.
  13. Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease.
  14. Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
  15. Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented.