All Comments by Benjamin Wolozin
- Synucleins are a novel class of substrates for G protein-coupled receptor kinases.
- Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
- Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain.
- Anti-amyloidogenic activity of tetracyclines: studies in vitro.
- Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response.
- Identification of estrogen target genes in human neural cells.
- MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males.
- Presenilin-1 mutations in Alzheimer's disease.
- Essential role for cholesterol in synaptic plasticity and neuronal degeneration.
- Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
- Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.
- Susceptibility locus for Alzheimer's disease on chromosome 10.
- Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease.
- Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling.
- Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented.