All Comments by Michael Lardelli
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- Patricidal Protein? Aβ42 said to Inhibit Its Parent, γ-Secretase
- Behold PANTHOS, a Toxic Wreath of Perinuclear Aβ That Kills Neurons
- Dysfunctional Lysosomes Cause Ferroptosis in Neurons
- New Mouse Models Better Mimic Tauopathy, Alzheimer's
- Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
- Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
- Alternative splicing in a presenilin 2 variant associated with Alzheimer disease.
- The National Institute on Aging and Alzheimer's Association research framework: A commentary from the Cochrane Dementia and Cognitive Improvement Group.
- Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.
- Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease.
- Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease.
- Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.
- Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
- Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ1-42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae.
- Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.