All Comments by Michael Lardelli

  1. Patricidal Protein? Aβ42 said to Inhibit Its Parent, γ-Secretase
  2. Behold PANTHOS, a Toxic Wreath of Perinuclear Aβ That Kills Neurons
  3. Dysfunctional Lysosomes Cause Ferroptosis in Neurons
  4. New Mouse Models Better Mimic Tauopathy, Alzheimer's
  5. Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
  6. Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.
  7. Alternative splicing in a presenilin 2 variant associated with Alzheimer disease.
  8. The National Institute on Aging and Alzheimer's Association research framework: A commentary from the Cochrane Dementia and Cognitive Improvement Group.
  9. Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.
  10. Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease.
  11. Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease.
  12. Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin.
  13. Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
  14. Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ1-42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae.
  15. Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.