A mouse study testing the combined effects of a BACE inhibitor and plaque-clearing antibody builds new support for a combination strategy aimed at reducing Aβ buildup in people.
Could tweaking methodologies improve amyloid diagnosis and tracking?
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
Mutated huntingtin may stow away in synaptic vesicles to sneak from one neuron to another.
At AAIC 2014, crenezumab Phase 2 trial results stirred debate.
Plenty of genetic risk factors for sporadic ALS are still waiting to be found, according to a new meta-analysis of GWAS data.
Heart-healthy foods containing omega-3 fatty acids, like salmon, slash risk of developing ALS by one-third.
The enzyme PARC acts as a survival factor in damaged neurons and cancer cells by targeting a pro-apoptotic protein for destruction.
The Alzheimer's Association International Conference 2014, held earlier this month in the Danish capital city of Copenhagen, featured no breakthroughs or major surprises, but instead numerous incremental steps toward a better grip on the disease garnered attention. Read here Tom Fagan’s and Gwyneth Zakaib’s accounts of the crenezumab Phase 2 results, preclinical combination therapy results, and scientists' attempts to diagnose Alzheimer’s in the eye. Learn about technical improvements in amyloid imaging, and an update on global efforts to rally against dementia. Over the course of this week, look for more stories on prevention trials, tau PET, and more.
- Michael van Es on Fishing for the ‘Missing Heritability’ of ALS
- Lary Walker on Huntington’s Protein Charged with Trans-synaptic Spread of Pathology
- Ammar Al-Chalabi on Fishing for the ‘Missing Heritability’ of ALS
- Marc Diamond on Huntington’s Protein Charged with Trans-synaptic Spread of Pathology
- Anne-Marie Wills on Heart-Healthy Fatty Acids May Stave Off ALS
- Ammar Al-Chalabi on HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter Release.
- Rodney Guttmann on Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice.