Aβ aggregates can assume a variety of structures that appear to have unique properties.
Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
Antipsychotic medications repurposed to accelerate autophagy might prevent cellular toxicity associated with mutant TDP-43.
An award-winning film follows a social worker set on bringing music to people with dementia, and documents their unforgettable moments of awakening.
Researchers retract two papers that claimed a quick dunk in acid turns mature mouse lymphocytes into pluripotent cells.
Families considering PGD to avoid passing on disease genes face obstacles such as high cost and invasive procedures.
Several thousand people have used preimplantation genetic diagnosis to avoid passing on pathogenic mutations to their babies, but many families with a history of Alzheimer’s or related diseases remain unaware of this option.
Some macrophages use their dying breath to emit a distress signal that could spell trouble for their neighbors.
After a number of trials suggested that supplements were ineffective in preventing chronic disease, researchers started asking whether the combination of healthy foods in a nutritious diet does a better job. To answer that question, AlzRisk, the database of epidemiological studies on risk factors for Alzheimer’s disease, examined the relationship between dietary pattern and dementia. Evaluation of the seven studies that met AlzRisk’s inclusion criteria supports the general idea that diets high in fruits and vegetables and low in red or processed meats—the Mediterranean diet, for example—reduce the risk of Alzheimer’s and dementia. AlzRisk curators conclude that benefits could stem from lowering cardiovascular risk, obesity, diabetes, reactive oxygen species, and inflammation. Check out the full entry and analysis on AlzRisk.
Could glia, the non-neuronal brain cells that crowd around neurons, be partly responsible for learning and memory deficits in Alzheimer's disease? Two recent papers suggest as much. Researchers report that in the hippocampi of mouse models of AD, reactive astrocytes ooze GABA. This inhibitory neurotransmitter then tempers excitatory signals, suppresses neural plasticity, and hinders learning and memory. The authors found hints of this imbalance in human brains, as well. The results could provide a new twist to impaired memory in early Alzheimer’s.
For families with autosomal-dominant neurological conditions, the fear of passing on the disease to their children looms large. Now, people at this highest genetic risk can ensure that they have healthy children by undergoing in vitro fertilization followed by genetic testing of embryos prior to implantation. Called preimplantation genetic diagnosis (PGD), the procedure remains rarely used, largely because few people know about it. Even fewer realize they can use it simply if they are at risk due to having an affected parent, and without having to find out their own genetic status. Madolyn Bowman Rogers reports.
- Lary Walker on More Evidence Ties Aβ Strains to Distinct Pathologies
- Jemeen Sreedharan on Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
- Meghan Mitchell on A Life of Cognitive Enrichment May Fend Off Dementia. But How?
- Seth Masters on Inflammasomes Spread from Cell to Cell
- Kumar Sambamurti on Scant α-Secretase Compensation for BACE Inhibition in Monkeys
- Brenda Plassman on Brain Injury Boosts Dementia Risk
- John Kauwe on Family History Accounts for Some of the Spread in Age at Onset of Familial Alzheimer's