A micro-immunoelectrode allows researchers measure Aβ levels in the interstitial fluid of mice every 30 seconds.
Basic preclinical discoveries keep meeting vibrant for neurodegenerative disease researchers from around the world
People who took prescription medications for hypertension were less likely than others to develop amyotrophic lateral sclerosis.
At Duke University, researchers discussed how injected stem cells might be tracked and used to treat neurodegenerative diseases.
Aβ and other pathogenic proteins may cause neurodegenerative disease by spreading throughout the brain like infectious diseases spread through populations, according to a new mathematical model.
Whether by themselves or in the company of mutations that cause frontotemporal dementia, microRNAs may play a hand in driving disease.
At ICFTD, researchers proposed new genes and explored genetic differences that contribute to the vast diversity of FTD clinical presentations.
In debating how C9ORF72 causes neurodegeneration, researchers struggle to connect cell-culture results with divergent patterns of human disease.
More than 31,000 people attended the annual Society for Neuroscience meeting in Washington, D.C., November 15-19. Twenty-five symposia, 26 minisymposia, 101 nanosymposia, 667 poster sessions, and numerous lectures, workshops, and satellite events attracted researchers from all walks of neuroscience. If you didn’t soak it all in, or if you opted for the relative calm of the lab this year, then check Alzforum in the coming weeks as Gwyneth Zakaib and Tom Fagan bring you highlights.
Abstracts are due by December 1 for The 3rd Wellcome Trust conference on Biomarkers for Brain Disorders: Challenges and Opportunities, to be held February 1-3, 2015, in Cambridge, U.K. Find instructions for submitting abstracts and further details at the conference website. Attendees must register by January 5, 2015.
Stem cells have not yet been tried in a clinical study for Alzheimer’s disease, but that may be about to change. At a Duke symposium, researchers discussed the move toward trials and barriers that remain.
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A recognition that microRNAs may powerfully influence the pathogenesis of frontotemporal dementia was on display at ICFTD conference held last month in Vancouver, Canada. It came amid a rapid stream of genetics news, as well as a deeper exploration of the unusual peptide and RNA biology of the disease-causing C9ORF72 repeat expansions. These topics wrap up Jessica Shugart’s and Gabrielle Strobel’s coverage of the meeting, where 590 scientists from 30 countries exchanged the latest clinical and scientific news on the heterogeneous set of diseases that make up FTLD. Taken together, multi-center cohort studies in Europe and North America, surprising insight into the physiological aspects of these diseases, and the advance of an HDAC inhibitor drug into Phase 2 all created a sense that the FTD field is poised for rapid progress.
- Jeffrey Cummings, Constantine Lyketsos, Pierre Tariot, Anton Porsteinsson and Elaine R Peskind on A New Drug to Calm Agitation, Uncontrollable Laughing and Crying, in Alzheimer’s?
- Benjamin Wolozin on Angiotensin-Converting Enzyme Inhibitors and Amyotrophic Lateral Sclerosis Risk: A Total Population-Based Case-Control Study.
- Dawn Kuzma on Too Hot, Too Cold, or Just Wrong? Physiology Links Behavior to Circuits in FTD
- Markus Damme, Thomas Reinheckel and Paul Saftig on Does Novel Tau Protease Promote Pathology?
- A. David Smith on Results of 2-year vitamin B treatment on cognitive performance: Secondary data from an RCT.
- Gregory Cole on Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.
- Lucia Banci on Aggregation propensities of superoxide dismutase G93 hotspot mutants mirror ALS clinical phenotypes.