Researchers have modeled a motor neuron in silico to show how energy shortage could lead to its degeneration in amyotrophic lateral sclerosis.
An active immunotherapy is coming to the fore as researchers continue to try novel therapies.
Repeat peptides made by the mutant C9ORF72 gene in ALS and FTD enter the nucleolus and obstruct RNA biogenesis.
Signals emanating from the prefrontal cortex play a role in forming memories in the hippocampus, a study reports. The finding could have implications for Alzheimer’s.
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Lifestyle changes to evade dementia, such as healthy eating and exercise, made a strong showing at the Alzheimer’s Association International Conference in Copenhagen, Denmark.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
In mouse models, Aβ aggregates injected into the belly invade the brain, as do prion seeds.
Held last month in Copenhagen, Denmark, the highs at this year's Alzheimer's Association International Conference included reviews of incremental advances toward a better grip on the disease. Alzforum's coverage continues with reports on the Phase 2 trial results of the active immunotherapy CAD106, a new BACE inhibitor, respectable results of a large behavioral intervention study, and more advances on the science front.
By simulating a motor neuron computationally, the authors of a new paper in Neuron have shown why those cells might be so prone to degeneration in ALS. Taking away a modest fraction of the neuron's energy supply made it impossible for sodium-potassium pumps to maintain membrane polarity, causing them to suck up more and more energy in a feedback loop that ultimately doomed the virtual neuron. This is the first example of a single-cell computational model for neurodegeneration, said study author Serge Przedborski of Columbia University in New York, but he hopes it will not be the last.
Researchers have developed a striking new technique that renders the whole body of a rodent clear and accessible to microscopic imaging. By sequentially pumping gels, detergents, and then fluorescent labels throughout the body’s vasculature, researchers can probe deep into all of its organs in subcellular detail. The new method will allow scientists to scrutinize neural circuitry not only within the brain and spinal cord, but throughout the peripheral nervous system. This new imaging access could facilitate detailed tracking of the origins and spread of neurodegenerative diseases.
What comes out when geneticists share data from 15 discrete GWAS studies on 19,000 people with Parkinson’s disease and some 100,000 controls? Twenty-eight genetic variants, some strongly confirmed, others popping up for the first time, plus a trove of data for researchers around the world to analyze. Funded and nudged along by the Michael J. Fox Foundation, the massive collaborative project makes its full results freely available on the all-new PDGene database. Led by Lars Bertram and Christina Lill, this public resource has been outfitted with new features, such as the ability for users to run customized meta-analyses of select data that most interest them, and to add their own lab’s genetic data into on-the-fly meta-analysis.
- Jiou Wang on C9ORF72 Killer Dipeptides Clog the Nucleolus
- Jochen Herms on Alzheimer’s Disease: In the Eye of the Patient?
- Sylvie Claeysen on An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice.
- Matthew Kirkcaldie and James Vickers on Does Glial Neurotransmission Impair Memory Circuits in Alzheimer’s?
- Dimitrije Krstic on Some Neurons Enlist Glia to Take Care of Their Trash
- Luc Buee on Reining in Calpain Tempers Tau and Delays Neurodegeneration
- Ashish Raj on Transparent Bodies Allow Neural Networks to ‘Apparate’