A broad genetic analysis suggests that mutations in a microtubule subunit enhance the risk for ALS.
A protein from the Borna disease virus rescues mitochondria and keeps stressed neurons viable, suggesting a new neuroprotective strategy.
MRI in mice could help explain disconnections in neural circuitry that precede amyloid plaques.
The severity of ALS correlates with how badly mutations destabilize superoxide dismutase 1, and promote its aggregation, according to a new study.
By beaming red light at a blood sample and measuring the scattered photons, scientists claim to identify people with Alzheimer’s disease.
Two trials suggest that a fixed combination of a cough medicine and a cardiac arrhythmia medicine might treat agitation and quiet emotional outbursts in people with Alzheimer’s.
People with moderate to severe Alzheimer’s have higher levels of orexin, a neuropeptide that keeps people awake, a study reports. The findings solidify links between orexin and sleep disturbances associated with the disease.
Aβ oligomers rapidly seed tau pathology in macaques, potentially providing a model for drug testing that better reflects human pathology.Aβ oligomers rapidly seed tau pathology in macaques, potentially providing a model for drug testing that better reflects human pathology.
Finding genetic variations that cause extremely rare conditions, such as amyotrophic lateral sclerosis, presents scientists with a major challenge. Now, using a novel, exome-based approach, an international group of researchers has turned up a potential risk factor for ALS in the TUBA4A gene, which codes for an isoform of α-tubulin. TUBA4A variants that associate with ALS weaken the microtubules that form the cytoskeleton, according to the research. The findings may help explain why neurons degenerate in this disease.
Not all viruses kill their prey. In fact, at least one virus that invades neurons preserves its hosts by turning off cell death pathways. Now, researchers have used this trick to stave off neurodegeneration. In Nature Communications, French researchers report that a protein from the Borna disease virus protects mitochondria and rescues neurons in a mouse model of Parkinson’s. A fragment of the protein may work as a neuroprotective agent.
At the 139th meeting of the American Neurological Association, held October 12-14 in Baltimore, scientists explained some of the newest therapies, preventative techniques, and diagnostic tests that may help control Alzheimer’s disease. An in vitro fertilization procedure has helped one woman who has early-onset Alzheimer’s in her family conceive twins with normal copies of the presenilin 1 gene. On the therapeutics front, a drug that is FDA-approved to quell uncontrollable laughing and crying reduced emotional outbursts and calmed patients with Alzheimer’s and other dementias. In addition, scientists reported that Raman spectroscopy of the blood might distinguish people with AD from healthy peers and people with other dementias.
Given that drugs that looked promising in Alzheimer mice have failed in human trials, is it time to find a better model? A new report claims that middle-aged macaque monkeys rapidly developed key features of AD, including neurofibrillary tangles, when Aβ oligomers were injected into their brains. Some researchers think these primates might provide a clearer picture of how AD therapeutics will perform in people.
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- Aaron Gitler on Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS
- Disha Shah on Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis.
- Lon Schneider on A New Drug to Calm Agitation, Uncontrollable Laughing and Crying, in Alzheimer’s?
- Henrietta Nielsen on Wake Up and Smell the … Orexin? Peptide Percolates in Alzheimer’s Brain
- Brendan Lucey on Wake Up and Smell the … Orexin? Peptide Percolates in Alzheimer’s Brain
- Tara Spires-Jones on Alzheimer’s in a Dish? Aβ Stokes Tau Pathology in Third Dimension
- Sanjay Pimplikar on Alzheimer’s in a Dish? Aβ Stokes Tau Pathology in Third Dimension