Heart-healthy foods containing omega-3 fatty acids, like salmon, slash risk of developing ALS by one-third.
The enzyme PARC acts as a survival factor in damaged neurons and cancer cells by targeting a pro-apoptotic protein for destruction.
Novartis Pharmaceuticals Corporation will partner with the Banner Alzheimer's Institute testing experimental preclinical therapies in the upcoming Alzheimer's Prevention Initiative ApoE4 study. The study complements the API ADAD trial.
In fruit flies that model ALS, presynaptic vesicles gather in unusually large clumps, amplifying signaling at the neuromuscular junction. Does this promote disease?
Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
In a large retrospective study, people with the highest plasma levels of an inflammatory protein experienced the greatest decline in reasoning abilities over the next 10 years.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
Aβ aggregates can assume a variety of structures that appear to have unique properties.
The Alzheimer’s Association International Conference 2014 drew more than 4,000 researchers to the Copenhagen Congress Center, pictured here under the shadow of the Bella Sky Hotel and a massive blade from one of the many wind turbines that stoke the Danes' electrical grid. Clinical trials, brain imaging, biomarkers, and intervention studies powered the meeting program. Data from Phase 2 clinical trials of crenezumab, an anti-Aβ antibody, disappointed, but positive results from a large Finish intervention study raised hope that lifestyle changes can pay dividends toward preventing dementia. The Alzheimer's Prevention Initiative announced a new partnership with Novartis to test if an Aβ vaccine or a BACE inhibitor can slow or prevent sporadic Alzheimer's in people who are genetically predisposed to the disease. Check Alzforum for continuing coverage as we bring you highlights from the meeting, which ran July 13-17 in the Danish capital.
After a number of trials suggested that supplements were ineffective in preventing chronic disease, researchers started asking whether the combination of healthy foods in a nutritious diet did a better job. To answer that question, AlzRisk, the database of epidemiological studies on risk factors for Alzheimer’s disease, examined the relationship between dietary pattern and dementia. Evaluation of the seven studies that met AlzRisk’s inclusion criteria supports the general idea that diets high in fruits and vegetables and low in red or processed meats—the Mediterranean diet, for example—reduce the risk of Alzheimer’s and dementia. AlzRisk curators conclude that benefits could stem from lowering cardiovascular risk, obesity, diabetes, reactive oxygen species, and inflammation. Check out the full entry and analysis on AlzRisk.
- Anne-Marie Wills on Heart-Healthy Fatty Acids May Stave Off ALS
- Ammar Al-Chalabi on HDAC6 Is a Bruchpilot Deacetylase that Facilitates Neurotransmitter Release.
- Rodney Guttmann on Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice.
- Peter Davies on Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice.
- Bart De Strooper and Lucia Chavez-Gutierrez on Scientists Pinpoint γ-Secretase Modulator Binding Spot
- Lary Walker on More Evidence Ties Aβ Strains to Distinct Pathologies
- Jemeen Sreedharan on Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.