A small Aβ fragment produced in healthy brains binds acetylcholine receptors and enhances synaptic plasticity and learning, while blocking the toxic effects of Aβ42.
Compounds derived from cocoa beans boost blood volume to part of the brain, and may counteract age-related decline in memory.
A broad genetic analysis suggests that mutations in a microtubule subunit enhance the risk for ALS.
A protein from the Borna disease virus rescues mitochondria and keeps stressed neurons viable, suggesting a new neuroprotective strategy.
MRI in mice could help explain disconnections in neural circuitry that precede amyloid plaques.
The severity of ALS correlates with how badly mutations destabilize superoxide dismutase 1, and promote its aggregation, according to a new study.
By beaming red light at a blood sample and measuring the scattered photons, scientists claim to identify people with Alzheimer’s disease.
Two trials suggest that a fixed combination of a cough medicine and a cardiac arrhythmia medicine might treat agitation and quiet emotional outbursts in people with Alzheimer’s.
Finding genetic variations that cause extremely rare conditions, such as amyotrophic lateral sclerosis, presents scientists with a major challenge. Now, using a novel, exome-based approach, an international group of researchers has turned up a potential risk factor for ALS in the TUBA4A gene, which codes for an isoform of α-tubulin. TUBA4A variants that associate with ALS weaken the microtubules that form the cytoskeleton, according to the research. The findings may help explain why neurons degenerate in this disease.
Not all viruses kill their prey. In fact, at least one virus that invades neurons preserves its hosts by turning off cell death pathways. Now, researchers have used this trick to stave off neurodegeneration. In Nature Communications, French researchers report that a protein from the Borna disease virus protects mitochondria and rescues neurons in a mouse model of Parkinson’s. A fragment of the protein may work as a neuroprotective agent.
At the 139th meeting of the American Neurological Association, held October 12-14 in Baltimore, scientists explained some of the newest therapies, preventative techniques, and diagnostic tests that may help control Alzheimer’s disease. An in vitro fertilization procedure has helped one woman who has early-onset Alzheimer’s in her family conceive twins with normal copies of the presenilin 1 gene. On the therapeutics front, a drug that is FDA-approved to quell uncontrollable laughing and crying reduced emotional outbursts and calmed patients with Alzheimer’s and other dementias. In addition, scientists reported that Raman spectroscopy of the blood might distinguish people with AD from healthy peers and people with other dementias.
- John Cirrito on Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal β-Amyloid Fragment.
- Erik Portelius on Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal β-Amyloid Fragment.
- Mark Cookson on A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson's disease.
- Rita Guerreiro on Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS
- Aaron Gitler on Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS
- Disha Shah on Early alterations in functional connectivity and white matter structure in a transgenic mouse model of cerebral amyloidosis.
- Lon Schneider on A New Drug to Calm Agitation, Uncontrollable Laughing and Crying, in Alzheimer’s?